Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but don't predict tissue iron levels in inbred mice
نویسندگان
چکیده
1 Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, 8 University of Edinburgh, Edinburgh, EH8 9AG, United Kingdom; 2 Department of Nutritional Science & 9 Toxicology, University of California, Berkeley, Berkeley, CA 94720; 3 Department of Food and Nutrition, 10 College of Human Ecology, Yonsei University, Seodaemun-gu, Seoul 120-749, Korea; 4 Department of 11 Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 12 90095; 5 Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, 13 Gainesville, FL 32610 14 15 Short title: Role of strain, sex and hepcidin in iron metabolism 16 17
منابع مشابه
Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice.
Iron homeostasis is tightly regulated, and the peptide hormone hepcidin is considered to be a principal regulator of iron metabolism. Previous studies in a limited number of mouse strains found equivocal sex- and strain-dependent differences in mRNA and serum levels of hepcidin and reported conflicting data on the relationship between hepcidin (Hamp1) mRNA levels and iron status. Our aim was to...
متن کاملEffect of iron overload on furin expression in wild-type and β-thalassemic mice
Furin is a proprotein convertase enzyme. In the liver, it cleaves prohepcidin to form active hepcidin-25, which regulates systemic iron homeostasis. Hepcidin deficiency is a component of several iron overload disorders, including β-thalassemia. Several studies have identified factors that repress hepcidin gene transcription in iron overload. However, the effect of iron overload on furin, a post...
متن کاملFerritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice.
Hepcidin is a hepatocellular hormone that inhibits the release of iron from certain cell populations, including enterocytes and reticuloendothelial cells. The regulation of hepcidin (HAMP) gene expression by iron status is mediated in part by the signaling molecule bone morphogenetic protein 6 (BMP6). We took advantage of the low iron status of juvenile mice to characterize the regulation of Bm...
متن کاملHepcidin deficiency and iron deficiency do not alter tuberculosis susceptibility in a murine M.tb infection model
Tuberculosis (TB), caused by the macrophage-tropic pathogen Mycobacterium tuberculosis (M.tb) is a highly prevalent infectious disease. Since an immune correlate of protection or effective vaccine have yet to be found, continued research into host-pathogen interactions is important. Previous literature reports links between host iron status and disease outcome for many infections, including TB....
متن کاملIntestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese.
Divalent metal-ion transporter-1 (DMT1) is a widely expressed iron-preferring membrane-transport protein that serves a critical role in erythroid iron utilization. We have investigated its role in intestinal metal absorption by studying a mouse model lacking intestinal DMT1 (i.e., DMT1(int/int)). DMT1(int/int) mice exhibited a profound hypochromic-microcytic anemia, splenomegaly, and cardiomega...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017